PROP members Mark Sullivan and Jane Ballantyne published this editorial in the American Journal of Psychiatry, rebutting and questioning the findings of Hasin et al. This article argues that the “opioid-adjusted” and “pain-adjusted” versions of the DSM-5 Opioid Use Disorder criteria are not more valid than the unadjusted versions. Opioid misuse and Prescription Opioid Use Disorder risk do not arise only from patient misbehavior or improper intentions. They are intrinsic to opioids and the roles they play in the human brain. Sullivan and Ballentyne Commentary